2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W015169S
    5-Methoxytryptamine-d4
    		99.7%
    5-Methoxytryptamine-d4 (O-Methylserotonin-d4) is the deuterium labeled 5-Methoxytryptamine (HY-W015169). 5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action.
    5-Methoxytryptamine-d<sub>4</sub>
  • HY-W107263
    4-Hydroxypentanoate sodium
    		Control 98.0%
    4-Hydroxypentanoate sodium, a sedative, is an active metabolite of gamma-Valerolactone (HY-W015938).
    4-Hydroxypentanoate sodium
  • HY-W010593
    Ethylenethiourea
    		98.0%
    Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active.
    Ethylenethiourea
  • HY-W016221S1
    6-Hydroxy Chlorzoxazone-15N,d2
    6-Hydroxy Chlorzoxazone-15N,d2 is the 15N and deuterium labeled 6-Hydroxy Chlorzoxazone (HY-W016221). 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
    6-Hydroxy Chlorzoxazone-<sup>15</sup>N,d<sub>2</sub>
  • HY-135407S
    N-Desethyl Oxybutynin-d5 hydrochloride
    		99.36%
    N-Desethyl Oxybutynin-d5 (hydrochloride) is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-dependent K+ channels.
    N-Desethyl Oxybutynin-d<sub>5</sub> hydrochloride
  • HY-153995A
    D-Ribonic acid
    D-Ribonic acid is a metabolite of D-Ribose (HY-113375). Ribonic acid is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid may participate in the mitochondrial energy production process.
    D-Ribonic acid
  • HY-W045132
    N-Desbutyl Bupivacaine
    N-Desbutyl Bupivacaine (compound 100) is a metabolite of Bupivacaine (HY-B0405), an NMDA receptor inhibitor and SCN5A antagonist.
    N-Desbutyl Bupivacaine
  • HY-133724
    Vardenafil N-oxide
    		99.57%
    Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442).
    Vardenafil N-oxide
  • HY-17528
    Cyhalofop
    Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Cyhalofop
  • HY-W588241
    Serotonin glucuronide
    Serotonin glucuronide is the product of Serotonin glucuronidation.
    Serotonin glucuronide
  • HY-137193
    5,6-Dihydroabiraterone
    5,6-Dihydroabiraterone is the metabolism of Abiraterone (HY-70013). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, and shows antitumor activity in CRPC (castration-resistant prostate cancer).
    5,6-Dihydroabiraterone
  • HY-W399311
    4-Hydroxyphenyl diphenyl phosphate
    4-Hydroxyphenyl diphenyl phosphate is a hydroxylated metabolite of organophosphate flame retardant.
    4-Hydroxyphenyl diphenyl phosphate
  • HY-148301
    6α-Hydroxyestradiol
    6α-Hydroxyestradiol, a hydroxyestrogen, is an Estradiol (HY-B0141) metabolite.
    6α-Hydroxyestradiol
  • HY-101671
    S-methyl-KE-298
    		98.0%
    S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298
  • HY-W012481
    Nirvanol
    Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders.
    Nirvanol
  • HY-G0008A
    O-Desmethyl Mebeverine alcohol hydrochloride
    		98.0%
    O-Desmethyl Mebeverine alcohol hydrochloride is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
    O-Desmethyl Mebeverine alcohol hydrochloride
  • HY-124414A
    4'-Hydroxytamoxifen TFA
    		99.43%
    4'-Hydroxytamoxifen TFA is a salt form of a metabolite of Tamoxifen. 4'-Hydroxytamoxifen TFA has a higher affinity for ER than Tamoxifen. 4'-Hydroxytamoxifen TFA induces non-apoptotic cytotoxicity in human endometrial adenocarcinoma cells.
    4'-Hydroxytamoxifen TFA
  • HY-133677S
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4 (MEHHP-d4) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono (2-ethyl-5-hydroxyhexyl) phthalate is a biomarker for human exposure to DEHP (HY-B1945). By activating the tryptophan-kynurenine-aryl hydrocarbon receptor (AhR) pathway, mono (2-ethyl-5-hydroxyhexyl) phthalate significantly increases the viability of primary uterine leiomyoma cells and reduces cell apoptosis. Mono (2-ethyl-5-hydroxyhexyl) phthalate correlates with decreased sperm DNA damage. Mono (2-ethyl-5-hydroxyhexyl) phthalate can be used in studies related to uterine leiomyoma.
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d<sub>4</sub>
  • HY-146269
    11-Desethyl Irinotecan
    11-Desethyl Irinotecan is a camptothecin (CPT) analog and one of the metabolites of irinotecan. It is promising for cancer research.
    11-Desethyl Irinotecan
  • HY-133673
    Mono(3-carboxypropyl) phthalate
    Mono (3-carboxypropyl) phthalate (MCPP) is a metabolite of Di-n-octyl phthalate. Di-n-octyl phthalate (DnOP) is a plasticizer used in polyvinyl chloride plastics, cellulose esters, and polystyrene resins.
    Mono(3-carboxypropyl) phthalate
Cat. No. Product Name / Synonyms Application Reactivity